DBCO-PEG4-NHS酯在pH 7-9的條件下能特異性且高效地與一級(jí)胺（例如，賴氨酸殘基的側(cè)鏈或氨基硅烷包覆的表面）反應(yīng)形成共價(jià)鍵。親水性的聚乙二醇（PEG）間隔臂賦予了水溶性，并提供了一個(gè)長(zhǎng)而靈活的連接，這極小化了與含有疊氮的互補(bǔ)分子連接時(shí)的立體阻礙。

艾美捷Click Chemistry Tools DBCO-PEG4-NHS酯 #CCT-A134規(guī)格：

單位規(guī)格 10毫克，4×2毫克，25毫克，100毫克，500毫克

分子量 649.68

化學(xué)成分 C34H39N3O10

CAS號(hào) 1427004-19-0

溶解性 DMSO、DMF、二氯甲烷（DCM）、四氫呋喃（THF）、氯仿

純度 >95%（高效液相色譜法，HPLC）

外觀 黃色至微橙色油狀物

儲(chǔ)存條件 -20攝氏度。保持干燥

運(yùn)輸條件 常溫

Click Chemistry Tools DBCO-PEG4-NHS酯文獻(xiàn)參考：

Wang X., et al. (2021). Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer. ACS Chem. Biol., 16 (4), 724-730. [PubMed]

Wiener, J., et al. (2020). Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics. Sci Rep., 10 (1), 1457. [PubMed]

Ahn, S.H., et al. (2020). Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid. Bioconjugate Chem., 31(4), 1177-87. [PubMed]

Pack, J., et al. (2020). Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles. Bioconjugate Chem., 31(5), 1408-16. [PubMed]

Miller, A. L., et al. (2019). Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery?. Polym. Chem., 10, 705-717. [Publishing]

Huynh, V., et al. (2018). Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels. Bioconjugate Chem., 57(13), 3406-10. [PubMed]

Nedrow-Byerst, J.R., et al. (2013). PSMA-targeted SPECT agents: mode of binding effect on in vitro performance. Prostate., 73(4), 355-62. [PubMed]

Click Chemistry Tools（CCT）一直致力于不斷開發(fā)和擴(kuò)展一系列連接產(chǎn)品。他們利用特別新的研究成果研發(fā)生產(chǎn)出新穎的交聯(lián)和標(biāo)記試劑。產(chǎn)品被廣泛用于藥物研發(fā)、癌癥治療以及各類診斷技術(shù)等。目前CCT的產(chǎn)品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯(lián)試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標(biāo)記試劑盒以及分選用底物等。艾美捷科技是Click Chemistry Tools（CCT）的中國(guó)代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。

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